Cardiovascular and Renal Biology
The 91做厙 Cardiovascular and Renal Biology team is a group of scientists and clinicians with interests in both veterinary and human health and disease.
The 91做厙 is a leading veterinary institute undertaking feline chronic kidney disease (CKD) research and is renowned for its clinical cardiology research.
The team is also composed of basic scientists with world-leading expertise in cardiovascular and renal biology.
Cardiovascular Biology
Cardiovascular cell biology is a particular focus, with 91做厙 academics working on human and animal endothelial and cardiac cells, leukocytes and platelets, and investigating mechanisms of vascular cell-cell communication.
Several groups also use in vivo models of cardiovascular regeneration, vascular and metabolic diseases to better understand physiological and pathological cardiovascular and cerebrovascular processes.
The research is relevant to the following conditions:
- Heart disease (Dr Caroline Pellet-Many, Dr Ashton Faulkner)
- Diabetes (Dr Matthew Gage, Dr Ashton Faulkner)
- Endothelial dysfunction (Professor Caroline Wheeler-Jones, Dr Liz Finding, Dr Helen Stolp, Charlotte Lawson)
- Endothelial extracellular vesicles (Charlotte Lawson)
- Atherosclerosis (Dr Christina Warboys, Dr Matthew Gage, Dr Caroline Pellet-Many, Dr Isabel Orriss)
- Cardiovascular calcification (Dr Isabel Orriss, Professor Caroline Wheeler-Jones)
- Insulin resistance (Dr Matthew Gage, Dr Christina Warboys)
- Inflammation (Professor Caroline Wheeler-Jones, Dr Matthew Gage, Dr Caroline Pellet-Many, Dr Christina Warboys, Dr Helen Stolp, Charlotte Lawson)
- Dysregulated angiogenesis (Professor Caroline Wheeler-Jones, Dr Liz Finding, Dr Ashton Faulkner)
- Metabolic syndrome (Dr Ashton Faulkner, Dr Matthew Gage, Dr Christina Warboys)
- Cerebrovascular and brain development (Dr Helen Stolp)
- Cardiovascular development (Dr Caroline Pellet-Many)
- Clotting disorders (Dr Liz Finding)
- Exercise (Dr Liz Finding)
Renal Biology (Dr Elisa Vasilopoulou, Professor Jonathan Elliott, Professor Hattie Syme, Dr Rosanne Jepson, Dr Rebecca Geddes, Dr Jack Lawson)
The renal biology focus is on the pathogenesis of kidney diseases. We are using in vitro and in vivo models to better understand the mechanisms that modulate the progression of kidney disease, including the effects of endothelial dysfunction and diabetes on kidney function. Areas of interest include the structure and function of the glomerular filtration barrier and the role of inflammation in kidney injury and repair.
We have a particular focus on naturally occurring chronic kidney disease (CKD) in the cat and its potential as a model for progression of tubulointerstitial fibrosi