Dr Ashton Faulkner
PhD
Lecturer in Biomedical Sciences
Department: Comparative Biomedical Sciences
Campus: Camden
Research Groups: Cardiovascular and Renal Biology
Dr Ashton Faulkner is a Lecturer in Biomedical Sciences and pursues a research programme in cardiovascular molecular metabolism.
The overarching research aim of the Faulkner lab is to further our mechanistic understanding of how molecular sensors and modulators of metabolism regulate cellular function in different cell types of the cardiovascular system. Of particular interest is understanding the molecular control of fatty acid channelling within vascular cells and how this is modulated during the establishment of cardio-metabolic disease. The goal is to harness this knowledge in the design of novel therapeutic interventions to facilitate cardiovascular protection and repair.
- Finding, E.J.T. Faulkner, A. Nash, L. & Wheeler-Jones, C.P.D. (2024). Equine endothelial cells show pro-angiogenic behaviours in response to FGF2 but not VEGF-A. International Journal of Molecular Sciences, 25: 6017
- Gu, Y. Avolio, E. Alvino, V V. Thomas, A C. Herman, A. Miller, P J. Sullivan, N. Faulkner, A. & Madeddu, P. (2023). The senolytic agent dasatinib reduces cardiac steatosis and improves diastolic function in obese, type 2 diabetic mice. Cardiovascular Diabetology, 22: 214.
- Jover, E. Faulkner, A. Madeddu, P. & Lopez-Andrés, N. (2022). Editorial: Inflammation, metabolism and epigenetics in valvular heart disease. Frontiers in Cardiovascular Medicine, 9: 880015.
- Lopez Rioja, A. Faulkner, A. & Mellor, H. (2022). srGAP2 terminates RhoA signaling to control the duration of thrombin-mediated endothelial permeability. Vascular Biology, 4 (1): K1-K10
- Faulkner, A. (2021). Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease. Biochemical Society Transactions, 49 (1): 507-517
- Jover, E. Fagnano, M. Cathery, W. Slater, S. Pisanu, E. Gu, Y. Avolio, E. Bruno, D. Baz-Lopez, D. Faulkner, A. Carrabba, M. Angelini, G. & Madeddu, P. (2021). Human adventitial pericytes provide a unique source of anti-calcific cells for cardiac valve engineering: Role of microRNA-132-3p. Free Radical Biology and Medicine, 165: 137-151
- Cathery, W. Faulkner, A. Jover, E. Rodriguez-Arabaolaza, I. Thomas, A. Avolio, E. Caputo, M. & Madeddu, P. (2021). Umbilical cord pericytes provide a viable alternative to mesenchymal stem cells for neonatal vascular engineering. Frontiers in Cardiovascular Medicine, 7: 609980
- Faulkner, A. Tamiato, A. Cathery, W. Rampin, A. Maria Caravaggi, C. Jover, E. Allen, S. Mellor, H. Hauton, D. Heather, L.C. Spinetti, G. & Madeddu, P. (2020). Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus. Diabetologia, 63 (10): 2205-2217
- Faulkner, A.* Avolio, E.* Thomas, A.C.* Dang, Z.* Batstone, T. Lloyd, G.R. Weber, R.J.M. Najdekr, L. Jankevics, A. Dunn, W.B. Spinetti, G. Vecchione, C. Puca, A.A. & Madeddu, P. (2020). Multi-omics analysis of diabetic heart disease in the <