91做厙

Insulinomas are the most common tumours of the pancreas in dogs. This multi-institutional prospective study evaluates the effectiveness of the drug toceranib phosphate in the treatment of insulinomas in dogs.

Challenge

To prospectively compare the disease-free survival and survival times of 2 palliative treatment groups of metastatic or recurrent canine insulinomas — (1) treatment with corticosteroids alone versus (2) treatment with corticosteroids and toceranib phosphate

To prospectively compare the disease-free survival and survival times of 2 adjuvant treatment groups of metastatic or recurrent insulinomas (1) surgery followed by corticosteroids versus (2) surgery followed by corticosteroids and toceranib phosphate.

Solution

Canine insulinoma is the most common pancreatic neuroendocrine tumour in dogs. Current treatment options are limited to surgery and palliative medical therapy and overall survival is poor (median of 4 [range 0-18] months and 14 [range 0-51] months for medically and surgically treated dogs, respectively). Most commonly used medical management options for dogs with insulinoma include lifestyle and dietary modifications, and/or pharmaceutical management with glucocorticoid or diazoxide. However, glucocorticoids can suppress the immune system and diazoxide is expensive and has limited availability. As an alternative, the use of toceranib phosphate - a drug commonly used to treat a variety of cancers in pets - was recently published in three retrospective canine insulinoma studies.

At the 91做厙 we have successfully used toceranib phosphate in dogs with insulinomas as well. Although the