91做厙

Professor Woledge sadly passed away in March 2015. For any queries regarding his work or any upcoming publications please contact Professor Alan Wilson, Professor Nancy Curtin or Dr Tim West.  

Biography

RCW obtained his BSc in Physiology in 1959 at University College London followed by research training with A.V.Hill 1959-62. He remained in UCL Physiology until his retirement in 2003, being Head of Dept (1988-1994) and Director of Institute of Human Performance in Stanmore (1994-2013). Since retirement he continued research work at Imperial College (until 2010), at Kings College London, at Queen Mary University London and more recently at the 91做厙 (until 2015).

Research

RCW's research concerns muscle contraction and in particular in-vitro measurement of the energetic cost of muscular activity. Since 1973 this research has been in collaboration with  (qv). They have investigated the muscle energetics of a number of different vertebrates (Frog, Tortoise, Lizard, Eel, Dogfish, Mouse) and sought theoretical explanations using crossbridge theories. Since 1985 RCW has been collaborating with Dr S.A. Bruce on investigations of human muscle strength and the weakness caused by age and hormonal status.

Selected Publications

Song W, Vikhorev PG, Kashyap MN, Rowlands C, Ferenczi MA, Woledge RC, MacLeod K, Marston S, Curtin NA. (2013) Mechanical and energetic properties of papillary muscle from ACTC E99K transgenic mouse models of hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol. Jun 1;304(11):H1513-24.

West TG, Toepfer CN, Woledge RC, Curtin NA, Rowlerson A, Kalakoutis M, Hudson P, Wilson AM. (2013) Power output of skinned skeletal muscle fibres from the cheetah (Acinonyx jubatus). J Exp Biol. Aug 1;216(Pt 15):2974-82.

Bieles JS, Bruce SA, Woledge RC. (2012) Menopause alters temperature sensitivity of muscle force in humans. Eur J Appl Physiol. Mar;112(3):1117-22

Park-Holohan S, Linari M, Reconditi M, Fusi L, Brunello E, Irving M, Dolfi M, Lombardi V, West TG, Curtin NA, Woledge RC, Piazzesi G. (2012) Mechanics of myosin function in white muscle fibres of the dogfish Scyliorhinus canicula. J Physiol. 590, 1973-1988.

Bickham DC, West TG, Webb MR, Woledge RC, Curtin NA, Ferenczi MA. (2011) Millisecond-scale biochemical response to change in strain. Biophys J. 2011 Nov 16;101(10):2445-54.

Barclay CJ, Woledge RC, Curtin NA. (2010) Is the efficiency of mammalian (mouse) skeletal muscle temperature dependent? J Physiol. 588(Pt 19):3819-31.

Barclay, C.J., Woledge, R.C. & Curtin, N.A. (2010). Inferring crossbridge properties from skeletal muscle energetics. Progress in Biophysics and Molecular Biology 102, 53-71.

Park-Holohan, S.-J., West, T.G., Woledge, R.C., Ferenczi, M.A., Barclay, C.J. & Curtin, N.A. (2010). Effect of phosphate and temperature on force exerted by white muscle fibres from dogfish. Journal of Muscle Research and Cell Motility 31, 35-44.

Mottram SL, Woledge RC, Morrissey D. (2009) Motion analysis study of a scapular orientation exercise and subjects' ability to learn the exercise. Man Ther 14 13-18.

Barclay, C.J., Woledge, R.C. & Curtin, N.A. (2009). Effects of UCP3 genotype, temperature and muscle type on energy turnover of resting mouse skeletal muscle. Pflugers Arch. (European Journal of Physiology) 457, 857-864. doi: 10.1007/s00424-008-0552-z.

Woledge, R.S., Barclay, C.J. & Curtin, N.A. (2009). Temperature change as a probe of muscle crossbridge kinetics: a review and discussion. Proceeding of the Royal Society B 276, 2685-2695.